Chemopreventive effects of orange peel extract (OPE). I: OPE inhibits intestinal tumor growth in ApcMin/+ mice.
Identifieur interne : 002329 ( Main/Exploration ); précédent : 002328; suivant : 002330Chemopreventive effects of orange peel extract (OPE). I: OPE inhibits intestinal tumor growth in ApcMin/+ mice.
Auteurs : Kunhua Fan [États-Unis] ; Naoto Kurihara ; Sadanori Abe ; Chi-Tang Ho ; Geetha Ghai ; Kan YangSource :
- Journal of medicinal food [ 1096-620X ] ; 2007.
English descriptors
- KwdEn :
- Adenomatous Polyposis Coli (genetics), Animals, Anticarcinogenic Agents (administration & dosage), Apoptosis, Citrus sinensis (chemistry), Colonic Neoplasms (pathology), Colonic Neoplasms (prevention & control), Diet, Fruit (chemistry), Intestinal Neoplasms (pathology), Intestinal Neoplasms (prevention & control), Male, Mice, Mice, Inbred C57BL, Phytotherapy, Plant Extracts (administration & dosage).
- MESH :
- chemical , administration & dosage : Anticarcinogenic Agents, Plant Extracts.
- chemistry : Citrus sinensis, Fruit.
- genetics : Adenomatous Polyposis Coli.
- pathology : Colonic Neoplasms, Intestinal Neoplasms.
- prevention & control : Colonic Neoplasms, Intestinal Neoplasms.
- Animals, Apoptosis, Diet, Male, Mice, Mice, Inbred C57BL, Phytotherapy.
Abstract
Orange peel is a rich source of flavonoids with polymethoxyflavones as major constituents, compounds associated with potential antioxidant, anti-inflammatory, and antitumor activities. We studied the effect of an orange peel extract (OPE) on intestinal tumor growth in Apc(Min/+) mice, a mouse model for human familial adenomatous polyposis (FAP). The OPE contained 30% polymethoxyflavones, a mixture that included tangeretin (19.0%), heptamethoxyflavone (15.24%), tetramethoxyflavone (13.6%), nobiletin (12.49%), hexamethoxyflavone (11.06%), and sinensitin (9.16%). Apc(Min/+) mice were fed one of four diets: (1) AIN-76A control diet; (2) a new Western-style diet (NWD), i.e., AIN-76A diet modified with decreased calcium, vitamin D, and methyl-donor nutrients and increased lipid content); (3) NWD with 0.25% OPE; and (4) NWD with 0.5% OPE, with all additives premixed in the diet. After 9 weeks of feeding NWD to the Apc(Min/+) mice, tumors increased mainly in the colon, with tumor multiplicity increasing 5.3-fold and tumor volume increasing 6.7-fold. After feeding 0.5% OPE in NWD, the development of tumors markedly decreased, with multiplicity decreasing 49% in the small intestine and 38% in the colon. NWD also led to increased apoptosis in intestinal tumors, and 0.5% OPE in NWD further increased apoptosis in tumors of the small and large intestine. Findings indicated that OPE inhibited tumorigenesis in this preclinical mouse model of FAP, and increased apoptosis may have contributed to this effect.
DOI: 10.1089/jmf.2006.0214
PubMed: 17472461
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Chemopreventive effects of orange peel extract (OPE). I: OPE inhibits intestinal tumor growth in ApcMin/+ mice.</title><author><name sortKey="Fan, Kunhua" sort="Fan, Kunhua" uniqKey="Fan K" first="Kunhua" last="Fan">Kunhua Fan</name><affiliation wicri:level="1"><nlm:affiliation>Strang Cancer Prevention Center at The Rockefeller University, New York, New York 10021, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Strang Cancer Prevention Center at The Rockefeller University, New York, New York 10021</wicri:regionArea><wicri:noRegion>New York 10021</wicri:noRegion></affiliation></author><author><name sortKey="Kurihara, Naoto" sort="Kurihara, Naoto" uniqKey="Kurihara N" first="Naoto" last="Kurihara">Naoto Kurihara</name></author><author><name sortKey="Abe, Sadanori" sort="Abe, Sadanori" uniqKey="Abe S" first="Sadanori" last="Abe">Sadanori Abe</name></author><author><name sortKey="Ho, Chi Tang" sort="Ho, Chi Tang" uniqKey="Ho C" first="Chi-Tang" last="Ho">Chi-Tang Ho</name></author><author><name sortKey="Ghai, Geetha" sort="Ghai, Geetha" uniqKey="Ghai G" first="Geetha" last="Ghai">Geetha Ghai</name></author><author><name sortKey="Yang, Kan" sort="Yang, Kan" uniqKey="Yang K" first="Kan" last="Yang">Kan Yang</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2007">2007</date><idno type="RBID">pubmed:17472461</idno><idno type="pmid">17472461</idno><idno type="doi">10.1089/jmf.2006.0214</idno><idno type="wicri:Area/PubMed/Corpus">000B47</idno><idno type="wicri:Area/PubMed/Curation">000B47</idno><idno type="wicri:Area/PubMed/Checkpoint">000B47</idno><idno type="wicri:Area/Ncbi/Merge">000697</idno><idno type="wicri:Area/Ncbi/Curation">000697</idno><idno type="wicri:Area/Ncbi/Checkpoint">000697</idno><idno type="wicri:doubleKey">1096-620X:2007:Fan K:chemopreventive:effects:of</idno><idno type="wicri:Area/Main/Merge">002408</idno><idno type="wicri:Area/Main/Curation">002329</idno><idno type="wicri:Area/Main/Exploration">002329</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Chemopreventive effects of orange peel extract (OPE). I: OPE inhibits intestinal tumor growth in ApcMin/+ mice.</title><author><name sortKey="Fan, Kunhua" sort="Fan, Kunhua" uniqKey="Fan K" first="Kunhua" last="Fan">Kunhua Fan</name><affiliation wicri:level="1"><nlm:affiliation>Strang Cancer Prevention Center at The Rockefeller University, New York, New York 10021, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Strang Cancer Prevention Center at The Rockefeller University, New York, New York 10021</wicri:regionArea><wicri:noRegion>New York 10021</wicri:noRegion></affiliation></author><author><name sortKey="Kurihara, Naoto" sort="Kurihara, Naoto" uniqKey="Kurihara N" first="Naoto" last="Kurihara">Naoto Kurihara</name></author><author><name sortKey="Abe, Sadanori" sort="Abe, Sadanori" uniqKey="Abe S" first="Sadanori" last="Abe">Sadanori Abe</name></author><author><name sortKey="Ho, Chi Tang" sort="Ho, Chi Tang" uniqKey="Ho C" first="Chi-Tang" last="Ho">Chi-Tang Ho</name></author><author><name sortKey="Ghai, Geetha" sort="Ghai, Geetha" uniqKey="Ghai G" first="Geetha" last="Ghai">Geetha Ghai</name></author><author><name sortKey="Yang, Kan" sort="Yang, Kan" uniqKey="Yang K" first="Kan" last="Yang">Kan Yang</name></author></analytic><series><title level="j">Journal of medicinal food</title><idno type="ISSN">1096-620X</idno><imprint><date when="2007" type="published">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adenomatous Polyposis Coli (genetics)</term><term>Animals</term><term>Anticarcinogenic Agents (administration & dosage)</term><term>Apoptosis</term><term>Citrus sinensis (chemistry)</term><term>Colonic Neoplasms (pathology)</term><term>Colonic Neoplasms (prevention & control)</term><term>Diet</term><term>Fruit (chemistry)</term><term>Intestinal Neoplasms (pathology)</term><term>Intestinal Neoplasms (prevention & control)</term><term>Male</term><term>Mice</term><term>Mice, Inbred C57BL</term><term>Phytotherapy</term><term>Plant Extracts (administration & dosage)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Anticarcinogenic Agents</term><term>Plant Extracts</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Citrus sinensis</term><term>Fruit</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Adenomatous Polyposis Coli</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Colonic Neoplasms</term><term>Intestinal Neoplasms</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Colonic Neoplasms</term><term>Intestinal Neoplasms</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Apoptosis</term><term>Diet</term><term>Male</term><term>Mice</term><term>Mice, Inbred C57BL</term><term>Phytotherapy</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Orange peel is a rich source of flavonoids with polymethoxyflavones as major constituents, compounds associated with potential antioxidant, anti-inflammatory, and antitumor activities. We studied the effect of an orange peel extract (OPE) on intestinal tumor growth in Apc(Min/+) mice, a mouse model for human familial adenomatous polyposis (FAP). The OPE contained 30% polymethoxyflavones, a mixture that included tangeretin (19.0%), heptamethoxyflavone (15.24%), tetramethoxyflavone (13.6%), nobiletin (12.49%), hexamethoxyflavone (11.06%), and sinensitin (9.16%). Apc(Min/+) mice were fed one of four diets: (1) AIN-76A control diet; (2) a new Western-style diet (NWD), i.e., AIN-76A diet modified with decreased calcium, vitamin D, and methyl-donor nutrients and increased lipid content); (3) NWD with 0.25% OPE; and (4) NWD with 0.5% OPE, with all additives premixed in the diet. After 9 weeks of feeding NWD to the Apc(Min/+) mice, tumors increased mainly in the colon, with tumor multiplicity increasing 5.3-fold and tumor volume increasing 6.7-fold. After feeding 0.5% OPE in NWD, the development of tumors markedly decreased, with multiplicity decreasing 49% in the small intestine and 38% in the colon. NWD also led to increased apoptosis in intestinal tumors, and 0.5% OPE in NWD further increased apoptosis in tumors of the small and large intestine. Findings indicated that OPE inhibited tumorigenesis in this preclinical mouse model of FAP, and increased apoptosis may have contributed to this effect.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country></list><tree><noCountry><name sortKey="Abe, Sadanori" sort="Abe, Sadanori" uniqKey="Abe S" first="Sadanori" last="Abe">Sadanori Abe</name><name sortKey="Ghai, Geetha" sort="Ghai, Geetha" uniqKey="Ghai G" first="Geetha" last="Ghai">Geetha Ghai</name><name sortKey="Ho, Chi Tang" sort="Ho, Chi Tang" uniqKey="Ho C" first="Chi-Tang" last="Ho">Chi-Tang Ho</name><name sortKey="Kurihara, Naoto" sort="Kurihara, Naoto" uniqKey="Kurihara N" first="Naoto" last="Kurihara">Naoto Kurihara</name><name sortKey="Yang, Kan" sort="Yang, Kan" uniqKey="Yang K" first="Kan" last="Yang">Kan Yang</name></noCountry><country name="États-Unis"><noRegion><name sortKey="Fan, Kunhua" sort="Fan, Kunhua" uniqKey="Fan K" first="Kunhua" last="Fan">Kunhua Fan</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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